Ages You Faster Despite Appearing Healthy

Disease Prevention vs. Longevity Optimization

That paper suggests that several nutritional supplements’ positive stage may not be enough for longevity. The degrees needed to reduce disease may not be the same as those needed to optimize longevity. Ames says:

I was curious about nutritional supplements in 2006. I worked on mitochondria, which make all of your ATP, the high-energy chemical that powers your metabolism. It bleeds oxidants, among other side effects. Oxidants mutate. They damage DNA.

They damage protein and molecules like radiation. Besides radiation, your aging mitochondria produce oxidants. Decays with age. I used to wonder, ‘If vitamin C and vitamin E do all these amazing things, I’m wondering about the different nutritional vitamins.’

I got thrilled about it and realized that people don’t consume balanced diets, therefore their bodies are constantly deficient in vitamins. They consume sugary drinks and empty carbohydrates without vitamins.

You desire 30 unique vitamins and minerals. Your body can’t manufacture minerals. You must eliminate them from your diet. As with dietary vitamins.”

In 2006, he published a theoretical paper2 proposing that when a cell becomes high on a vitamin, it begins to ration it, favoring protein enzymes needed for rapid survival over those that prevent long-term diseases like most cancers and heart disease.

Many proteins include every nutrient. Zinc is in 2,000 proteins, magnesium 300. Only 5 proteins contain biotin, the fewest. This nutrient limitation may begin a decade or more before most malignancies or heart disease (or other major diseases) appear.

Ames: “So, what you’re doing is buying and selling long-term well-being for short-term well-being.” “Chances are you’ll look fine, but if you’re not eating well, you’re aging fast.”

The Ames Triage Idea

He called this food rationing approach triage,3 after French medical physicians’ combat time period in World War I. Due to staffing shortages, wounded troopers were classified into three teams: those who would die without treatment, those who would survive with care, and those who would survive with care. Doctors handled the third group, where their time and power were most useful.

“Dr. Joyce McCann, a great scientist in my lab, said, ‘Let’s look at this concept. Let’s review the literature on one vitamin and mineral. Vitamin K2, which affects 16 proteins, and selenium, which affects 25 proteins, were chosen. In 9 months, she bought a scientific paper4 showing that each has a triage system, says Ames.

Vitamin K2 is easy to identify since many of its proteins are involved in blood clotting. You must clot to survive; otherwise, you will die. Blood-clotting proteins may be vitamin Okay-dependent. These get vitamin K2 first. Selenium proved to be identical.

The starving proteins may prevent most malignancies and heart disease. Recently published paper5: “Prolonging Wholesome Getting old: Longevity Nutritional vitamins and Proteins shows that our poor diets will contribute to aging.

Many Lack Vital Vitamins for Longevity

In his research, he ranks vitamins by importance, many of which people are deficient in, based on the projected common demand. For instance:

The EAR says 70% of people don’t get enough vitamin D.

According to the EAR, 60% of individuals do not receive enough vitamin E, and 45% do not receive enough magnesium.

Even for disease prevention, the EAR criterion should not be optimal because it ignores long-term health. Current evidence says an excellent vitamin D level is 60–80 ng/mL, indicating that 85%–90% of the population is poor.

Solar exposure provides most vitamin D. The sunshine vitamin is made from ldl cholesterol, which is converted into vitamin D by UV light. It is an important steroid hormone that activates genes.

Although Ames takes “a lot of nutritional vitamins,” he has had a healthy, pure diet most of his life. Ideally, your diet provides most of your vitamins and minerals. Leafy greens are a good source of magnesium, which is found in chlorophyll.

Similarly, folic acid originates from “folia,” Latin for leaf. He explains, “My mentor on the California Institute of Know-how (Caltech) first remoted folic acid from 4 tons of spinach.” “Folate simply means the salt, and folic acid is the acid.”

Omega-6 to Omega-3 Ratio Is Essential for Health Omega-6s and omega-3 lipids are crucial for healthy aging. Famed by Ames:

“The mind needs omega-3s. We like them all. Our cooking oils are mostly omega-6s, and your body cares about the ratio. We’re all poor unless you eat a lot of omega-3-rich seafood.

Former postdoc Dr. Rhonda Patrick [Ph.D.] has published a beautiful work. Alzheimer’s is caused by the Apolipoprotein E4 gene. One copy of that gene triples your Alzheimer’s risk. Two copies give you 15 chances.

Having one copy and getting a concussion will cause Alzheimer’s. It’s crucial. She discovered the method, which involves delivering omega-3 into the mind via fatty acids.

The blood-brain barrier deteriorates with age. The mechanism for putting that into the mind doesn’t work well when you’re old like me—I was 90 in December 2018. She gathers evidence that THAT causes Alzheimer’s.”

The ideal omega-3-to-omega-6 fat ratio is 1-to-1 to 1-to-5, whereas Western diets are 1-to-20 to 1-to-50. You normally have to do two things to correct this imbalanced omega-3 to omega-6 ratio: Most people, especially individuals, are accountable.

Avoid processed foods and overcooked vegetable oil to reduce broken omega-6 intake. Corn oil, canola oil, soy oil, hydrogenated or partially hydrogenated fat, margarine, and shortening are common omega-6 sources to avoid.

Increase your animal-based omega-3 intake. Sardines, anchovies, herring, wild-caught Alaskan salmon, and krill oil are good sources.

Different Vital Longevity Vitamins

Besides nutritional vitamins and minerals, Ames’ research discusses several other vitamins that seem crucial for life, such as ergothioneine, an amino acid found in mushrooms and classified as “conditionally important.” His explanation:

Some vitamins are from specific sources. Ergothioneine is not a vitamin, yet many people say it is. It helps the body. It returns from mushrooms and fungi.”

Some good lifespan supplements (not all in Ames’ paper) are:

Glutathione production requires N-acetyl cysteine (NAC). It boosts glutathione production, an antioxidant your body makes naturally that reduces free radical damage and detoxifies heavy metals and other harmful compounds.

Nicotinamide adenine dinucleotide (NAD), a metabolic coenzyme produced by vitamin B3 (niacin). Poly ADP-ribose polymerase (PARP), one of many DNA repair processes, requires NAD sufficiency. Ames says:

“50 enzymes search your DNA for problems. When they see an unnecessary hump, they decrease and fill it. That restores DNA. Since they all need magnesium, magnesium is vital. It hasn’t been shown, but magnesium shortage may cause more mutations.

NAD coenzyme can be ensured by taking enough niacin. However, your body has a very efficient salvage pathway that recycles much of the NAD in your body, but if you’re abusing your body with electromagnetic fields and other oxidative stress that damage DNA and deplete NAD by PARP consumption, you may want to consider an augmentation program.

Zeaxanthin, lutein, and astaxanthin-like carotenoids.

Choline is needed to detoxify soluble poisons we encounter daily. Your body makes some choline, but not enough.

It can be taken as a supplement, however it’s usually a phospholipid like phosphatidylcholine. Egg yolks are a major source of choline. Patrick’s work on omega-3s and Alzheimer’s confirmed that phosphatidylcholine transports omega-3s to the brain.

Acetyl-L-carnitine (rare L-carnitine) improves memory. Ideal daily intake is 2,000–2,500 mg. After many weeks, most notice a difference.

Alpha lipoic acid, an antioxidant that improves mitochondrial health and prevents Alzheimer’s.

Extra Info

at his work “Latitude Mismatch,” Ames highlights the importance of vitamin D supplementation for those with dark skin at northern latitudes, where they don’t make enough.

“We’re trying to figure out why African-Americans have higher rates of certain birth defects, most cancers, and heart disease. Vitamin D may clarify it more, he believes. Vitamin D turns 2,700 genes on and off. It is a crucial chemical.

My paper clarifies that vitamins aren’t drugs. Scientific drug trials include no one taking the medicine. If you do it with a nutrient, half the population may have it, washing out your research and making them all negative.

Measure it first and never gaze at it on people who have enough. Finally, measure it to ensure you gave enough to raise the degrees to the right levels.”

To learn more about longevity-promoting vitamins and minerals, I recommend Ames’ paper,6 “Prolonging Wholesome Nutritional vitamins and proteins for longevity.”

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